Hydrationqualità Unreviewed (AI)LIT-0112
Long-Term Efficacy and Tolerability of an Emollient Containing Glycerol and Paraffin for Moderate-to-Severe Uremic Xerosis: A Randomized Phase 3 Study. (Dermatol Ther (Heidelb), 2024)
randomized phase 3
Fenoteca
EU entry #11096 · fonte CosIng
GLYCERIN
P1 · deepL5 · evidenza quantitativa
- CAS
- 56-81-5
- EC
- 200-289-5
- Evidenze
- 9
- Confidenza max
- 0.80
DENATURANTHAIR CONDITIONINGHUMECTANTORAL CAREPERFUMINGSKIN CONDITIONINGSKIN PROTECTINGSOLVENTVISCOSITY CONTROLLING
Profilo di predizione
Valore e confidenza sono output separati (regola R04); ogni riga è tracciabile alla sua base (R07).
Conoscenza diretta / funzionale
Transepidermal water lossconfidenza alta
basi: coefficient:C0-0001 · CosIng function=SKIN PROTECTING; prior_strength=0.25 — evidenze 0 · coefficienti 1
Stratum corneum hydrationconfidenza media
basi: CosIng function=HUMECTANT; prior_strength=0.55 · CosIng function=SKIN CONDITIONING; prior_strength=0.1 — evidenze 0 · coefficienti 0
Agente di ricerca live
Cerca ulteriore letteratura per questa voce (Europe PMC + PubChem, estrazione abstract-only, tutto etichettato «da revisionare»).
Evidenze citate
Hydrationqualità Unreviewed (AI)LIT-0113
Enhancement of water homeostasis by glycerol and urea in stratum corneum and the difference in the activity between them. (Int J Cosmet Sci, 2025)
Barrier/TEWLqualità Unreviewed (AI)LIT-0114
In Vivo Two-Dimensional Correlation Raman Spectroscopy Unveiling the Reversible Microstructural Changes and Spatially Differential Swelling of the Human Stratum Corneum in Response to Glycerin as a Temporary Penetration Enhancer. (Anal Chem, 2026)
Elasticityqualità Unreviewed (AI)LIT-0115
Bio-Revitalizing SkinGlow: Assessing the Efficacy of Microcannula-Assisted Treatment With Cohesive Polydensified Matrix Hyaluronic Acid With Glycerol (Belotero Revive) Through Ultrasound Elastography and Corneometry. (J Cosmet Dermatol, 2025)
Hydrationqualità Unreviewed (AI)LIT-0116
Glycerol and natural sugar-derived complex modulate differentially stratum corneum water-binding properties and structural parameters in an in vitro Raman-desorption model. (J Biophotonics, 2023)
Safety/Irritationqualità Unreviewed (AI)LIT-0117
Safety Assessment of Glycerin Ethoxylates as Used in Cosmetics. (Int J Toxicol, 2025)
Unspecifiedqualità Unreviewed (AI)LIT-0118
Facial Skin Revitalization With CPM-HA20G (Hyaluronic Acid + Glycerol): A Comparative Case Series Using Three Delivery Techniques With Ultrasound Confirmation. (J Cosmet Dermatol, 2026)
Hydration / TEWL7%, 10%, 40%qualità HighEV-0004
Clear dose discrimination among 7%, 10%, 40%; 40% glycerol produced highest hydration and about two-fold TEWL drop
Human instrumental comparative prototype study · n=12 women · 1 h and 5 h after single application
Hydration / TEWL20%qualità HighEV-0005
20% glycerin significantly increased corneometer hydration; no demonstrated influence on TEWL or SLS sensitivity
Human bilateral double-blind placebo-controlled · n=17 healthy volunteers · 10 days
Coefficienti C0
Immutabili (R02): gli aggiornamenti creano nuove versioni.
| ID | Endpoint | Dose | Valore | Evidenza |
|---|---|---|---|---|
| C0-0001 | TEWL | 40% | ~0.5 ratio | EV-0004 |
Fonte identità: CosIng (Commissione Europea). Questa scheda è uno strumento professionale di esplorazione: non è un giudizio sul prodotto finito né una valutazione di sicurezza.